Cellular Optimization & Genetic Insights

In under 6 minutes, each patient receives:

• A personalized health score
   
• Tailored system recommendations
   
• The mechanistic rationale behind each recommendation
   
• Links to peer-reviewed evidence
   
• Dosing and timing optimized using chronobiology and circadian science
   

All products are shipped directly to the patient for convenience and adherence.

APOA2

• Function: Lipid metabolism, response to saturated fat
   
• Health Category: Cardiovascular, Metabolic
   
• Clinical Applications: Hyperlipidemia, cardiovascular risk, obesity
   
• System Recommendation: Lipid-focused system, nutrigenomic lipid modulation
   

FTO

• Function: Energy balance, appetite regulation
   
• Health Category: Metabolic, Obesity, Cardiovascular
   
• Clinical Applications: Obesity, insulin resistance, type 2 diabetes, metabolic syndrome
   
• System Recommendation: Personalized metabolic system, chrono-nutrition timing
   

ADIPOQ

• Function: Adiponectin regulation, insulin sensitivity
   
• Health Category: Metabolic, Cardiovascular
   
• Clinical Applications: Type 2 diabetes, obesity, cardiovascular risk
   
• System Recommendation: Metabolic system with insulin sensitizers & mitochondrial support
   

CYP1A2

• Function: Caffeine & xenobiotic metabolism; oxidative stress
   
• Health Category: Cardiovascular, Neurological
   
• Clinical Applications: Hypertension, myocardial infarction risk, anxiety/insomnia, drug metabolism
   
• System Recommendation: Caffeine moderation, methylation support, antioxidant system
   

PPARD

• Function: Fatty acid oxidation, energy metabolism
   
• Health Category: Metabolic, Cardiovascular
   
• Clinical Applications: Dyslipidemia, insulin resistance, obesity, metabolic flexibility
   
• System Recommendation: Omega-3 & mitochondrial support system
   

ACTN3

• Function: Muscle fiber composition
   
• Health Category: Musculoskeletal, Fitness
   
• Clinical Applications: Sarcopenia, athletic performance, injury risk
   
• System Recommendation: Muscle support system (MyHMB®, creatine)
   

Note: These are examples. The full DNA panel includes 37 genes affecting metabolism, cardiovascular health, neurological function, hormonal balance, and fitness.
 

MTHFR

• Function: Folate → 5-methyl-THF
   
• Health Category: Cardiovascular, Neurological, Perimenopause
   
• Clinical Applications: ↑ Homocysteine, vascular inflammation, depression, menopause symptoms
   
• System Recommendation: 5-MTHF + methyl B12 + B6 system
   

COMT

• Function: Catecholamine & estrogen detox
   
• Health Category: Neurological, Hormonal, Perimenopause
   
• Clinical Applications: Anxiety, ADHD, estrogen dominance, menopause symptoms
   
• System Recommendation: B-vitamin & antioxidant system
   

VDR

• Function: Vitamin D receptor
   
• Health Category: Musculoskeletal, Immune
   
• Clinical Applications: Osteoporosis, immune dysregulation, muscle weakness
   
• System Recommendation: Vitamin D & mitochondrial system
   

BHMT

• Function: Alternative homocysteine remethylation pathway
   
• Health Category: Cardiovascular, Neurological
   
• Clinical Applications: Elevated homocysteine, methylation deficits
   
• System Recommendation: Methylation & betaine support system
   

CBS

• Function: Homocysteine breakdown
   
• Health Category: Cardiovascular, Neurological
   
• Clinical Applications: Oxidative stress, endothelial dysfunction, neurotoxicity
   
• System Recommendation: Antioxidant + methylation system
   

MTR

• Function: Homocysteine → methionine
   
• Health Category: Cardiovascular, Neurological
   
• Clinical Applications: DNA repair impairment, cardiovascular disease
   
• System Recommendation: Methylation system with B vitamins
   

MTRR

• Function: Regenerates MTR
   
• Health Category: Cardiovascular, Neurological, Hormonal
   
• Clinical Applications: Cardiovascular risk, homocysteine accumulation, methylation impairment
   
• System Recommendation: Methylcobalamin & methylation system support
   

Note: These are examples. The full methylation panel includes 16 genes, providing insight into methylation capacity, detoxification efficiency, neurotransmitter metabolism, and hormonal balance.
 

CYP1A2 is the main enzyme metabolizing ~95% of caffeine. Genetics influence fast or slow metabolizer phenotypes:

• Slow metabolizers (CYP1A2 C allele): Prolonged caffeine exposure, higher risk of hypertension, heart attack, anxiety, and sleep disturbances.
   
• Fast metabolizers (CYP1A2 AA allele): Faster caffeine clearance but increased oxidative stress, which can overwhelm methylation pathways (MTHFR, MTR, MTRR, COMT) if low-function alleles are present.
   

Clinical Insight: Personalized caffeine guidance, antioxidant support, and methylation systems are recommended to optimize metabolism and reduce cardiovascular and neurological risks.

• Preserves lean muscle mass via inhibition of the ubiquitin-proteasome pathway
   
• Improves recovery and functional independence
   
• Supports mTOR pathway for anabolic activity
   
• Relevant for adults 40+, injury recovery, and frailty prevention
   
• Evidence: Zhang et al., 2023; Meta-analysis, HMB in elderly populations
   

• Increases cellular energy availability, supporting muscle contraction and nutrient delivery
   
• Enhances vasodilation for blood flow and oxygenation
   
• Supports cognitive alertness indirectly via improved circulation
   
• Relevant for fatigue resistance, cognitive preservation, cardiovascular flow
   
• Evidence: Wilson et al., 2013; Purpura et al., 2017
   

• Neuroprotective: enhances ATP in brain cells, memory, cognition
   
• Supports muscle strength & bone density to reduce fall risk
   
• Improves glucose metabolism and insulin sensitivity
   
• Evidence: Hasselbalch et al., 2023
   

Synergy: Together, these systems combat muscle atrophy, restore cellular energy metabolism, reduce oxidative stress, and support mobility, performance, and independence.

Over 90,000 documented interactions, including:

• 30,000+ drug–nutrient depletions (e.g., statins depleting CoQ10)
   
• 20,000+ absorption conflicts (e.g., calcium impairing iron absorption)
   
• 10,000+ metabolic pathway competition (e.g., CYP450 interactions with folate)
   
• 30,000+ clinically observed adverse/synergistic effects
   

Databases referenced: Micromedex, Natural Medicines, FDA, NIH, EMA, PubMed, Lexicomp, DrugBank

Bottom Line: Clinicians cannot track all interactions manually—AI-enabled systems ensure precision, safety, and personalized optimization.

Every system is dosed and timed according to circadian rhythms to:

• Maximize absorption and efficacy
   
• Align with natural hormonal cycles
   
• Reduce side effects and oxidative stress
   
• Support mitochondrial and metabolic efficiency
   

✅ Summary:

• DNA panel and methylation panel provide insight into 37 and 16 genes, respectively.
   
• Systems address metabolism, methylation, cardiovascular, neurological, hormonal, musculoskeletal, and anti-aging health.
   
• Recommendations are personalized, science-driven, and optimized for timing, dosing, and delivery.