Achieve Optimal Health with The Practical Practitioner

• Preserves Lean Muscle Mass:
  Age-related sarcopenia (muscle loss) accelerates after age 40. HMB slows muscle degradation by inhibiting the ubiquitin-proteasome pathway.
   
• Improves Recovery:
  Faster repair of muscle tissue → less soreness, improved functional independence.
   
• Supports mTOR Pathway:
  Key pathway in maintaining anabolic activity in aging cells.
   

🧠 Relevant for: age 40+, injury recovery, frailty prevention.

• Increases Cellular Energy Availability:
  Extracellular ATP declines with age. Supplementation supports energy-demanding processes like muscle contraction, mitochondrial signaling, and nutrient delivery.
   
• Enhances Vasodilation:
  Improves blood flow and oxygenation, critical for aging tissues and brain perfusion.
   
• Supports Cognitive Alertness (Indirect):
  Increased circulation = improved nutrient delivery to the brain.
   

🧠 Relevant for: fatigue resistance, cognitive preservation, cardiovascular flow.

• Neuroprotective Effects:
  Enhances ATP in brain cells, protects against neurological decline, improves memory and processing in older adults.
   
• Increases Muscle Strength and Bone Density:
  Reduces fall risk and supports active aging.
   
• Improves Glucose Metabolism:
  Better insulin sensitivity helps counter age-related metabolic slowdown.
   

🧠 Relevant for: brain aging, strength maintenance, metabolic protection.

Together, these three ingredients:

• Combat muscle atrophy and cognitive decline
   
• Restore cellular energy metabolism
   
• Reduce oxidative stress and recovery time
   
• Support mobility, performance, and independence
   

This is not a sports-only stack. When taken consistently, it becomes a frontline anti-aging tool—especially for individuals 40+, menopausal women, and anyone facing mitochondrial decline or metabolic slowdown.

• Zhang et al., 2023 – Effects of β‑Hydroxy‑β‑Methylbutyrate Supplementation in Older Adults with Sarcopenia: RCT, 12 weeks.
  Demonstrated significant improvements in handgrip strength, gait speed, chair‑stand performance, muscle quality, and reduced inflammation in adults 60+ on HMB + resistance training.
   
• Meta-analysis – HMB efficacy in elderly populations.
  Found HMB boosts muscle strength and functional performance, particularly in individuals ≥ 70 years 
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• Wilson et al., 2013 / Purpura et al., 2017 – 400 mg ATP + training in resistance-trained adults.
  Enhanced lean mass, strength, power, and reduced muscle damage during overreaching periods
   
• Hasselbalch et al., 2023 Pilot (PubMed) – 20 g/day creatine in Alzheimer’s patients over 8 weeks.
  Increased brain creatine levels (+11%) and significant improvements in memory and cognition.