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Transform your health today

Nutrigenomics is the future and the future is NOW!

You don't HAVE to be sick and tired.

 

Proactive healthcare isn’t about putting out fires—it’s about stopping them before they start.
By integrating precision nutrition, drug-nutrient interaction management, and chronobiology-driven protocols, you build resilience at the cellular level—preventing dysfunction, optimizing metabolism, and preserving health.

That’s the power of shifting from reactive treatment to proactive prevention.

 


Basis

  • Emphasize prevention and optimization over reactive care
     
  • Use precision nutrition to proactively address health before symptoms appear
     

Nutrigenomics for Personalized Nutrition

  • Tailor supplement plans based on genetic nutrient metabolism, compromised methylation pathways and absorption profiles
     
  • Optimize nutrient intake for individual biological needs
     

Drug-Nutrient Interaction Identification

  • Proactively flag common medications known to deplete essential nutrients
     
  • Recognize how drugs impact nutrient status, absorption, and utilization
     
  • Prevent secondary nutrient deficiencies caused by pharmaceutical therapies
     

Targeted Supplementation Strategy

  • Customize nutrient support to counteract drug-induced depletion
     
  • Maintain optimal nutrient levels to support metabolism, immunity, and recovery
     
  • Reduce side effects and improve overall patient resilience
     

Chronobiology-Based Timing

  • Align supplementation with circadian rhythms to maximize absorption and effectiveness
     
  • Support detoxification and energy cycles through optimized timing
     

Clinical Workflow Integration

  • Incorporate drug-nutrient interaction checks into patient assessments
     
  • Educate patients on importance of nutrient support during medication regimens
     
  • Use biometrics and feedback to adjust supplementation proactively
     

Outcome Goals

  • Minimize nutrient deficiencies that impair recovery or cause new health issues
     
  • Enhance quality of life and functional capacity through balanced nutrient-drug management
     
  • Establish a prevention-focused, data-driven healthcare model
     

This approach ensures nutrient integrity isn’t compromised by medications, empowering clinicians to safeguard patient health with targeted, science-driven nutrition protocols.





 

  • Ordovas & Smith, 2019 — Nutrigenomics and Precision Nutrition (Nature Reviews Genetics)
     
  • Corella & Ordovas, 2014 — Nutrigenomics in Cardiovascular Medicine (Circulation Research)
     
  • Flint et al., 2016 — Drug-Induced Nutrient Depletion (American Journal of Medicine)
     
  • Boullata & Nace, 2011 — Drug-Nutrient Interactions (Nutrition in Clinical Practice)
     
  • Ruben et al., 2019 — Circadian Rhythms and Metabolism (Science)
     
  • Antoni et al., 2018 — Chronotherapy and Metabolic Health (Trends in Endocrinology & Metabolism)
     
  • Kavousi et al., 2020 — Personalized Prevention of Cardiovascular Disease (European Heart Journal)
     
  • Rappaport et al., 2016 — Exposome and Disease Prevention (Annual Review of Public Health)

Our Platform Cross References Real science

In less than 6 minutes each patient gets a health score, recommendations, WHY those recommendations and the peer reviewed studies behind it. Every recommendation is dosed and timed specifically for that individual using chronobiology and circadian rhythms based on that science. Our facility will ship directly to them!



Examples

Example:

Reason based on answer:

Sun: 60 + minutes

Supplementation with Omega-3 fatty acids is recommended for individuals who are in the sun for prolonged periods of time. Increased levels of sun exposure have been shown to have potentially damaging effects on the skin. Medical literature indicates that Omega-3 fatty acids can protect the skin from the inflammatory response caused after sun exposure and that these nutrients can reduce the risk of non-melanoma skin cancer.

Evidence::Rhodes LE, Shahbakhti H, Azurdia RM, Moison RM, Steenwinkel MJ, Homburg MI, Dean MP, McArdle F, Beijersbergen van Henegouwen GM, Epe B, Vink AA. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers. Carcinogenesis. 2003 May,24(5):919-25. Rhodes LE, Durham BH, Fraser WD, Friedmann PS. Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption. J Invest Dermatol. 1995 Oct,105(4):532-5.

Reason based on answer:

Fish Intake: None

Including wild salmon and other fish containing Omega-3 essential fatty acids in your diet can have a very positive effect on health. Omega-3 offers cardiovascular benefits, and can be instrumental in preventing heart attacks and strokes. However, Omega-3 cannot be synthesized by the human body. Numerous studies have shown the anti-inflammatory properties of Omega-3 and its role in promoting cognitive function as well as the prevention of chronic diseases. Supplementation with Omega-3 Complex is recommended for individuals 26 and older to prevent a deficiency, which may contribute to depression, decreased memory function, and heart and circulatory problems.

Evidence::Harris WS. Extending the cardiovascular benefits of omega-3 Fatty acids. Curr Atheroscler Rep. 2005 Sep;7(5):375-80. Moore CS, Bryant SP, Mishra GD, Krebs JD, Browning LM, Miller GJ, Jebb SA. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. Nutrition. 2006 Oct;22(10):1012-24.

Reason based on answer:

Family History: Cardiovascular Disease

A recent meta-analysis study published in the Journal of American Heart Association offers evidence of the significant protective effects of omega 3s against cardiovascular disease (CVD) risk. This meta-analysis included three recently completed large-scale trials, which increased the sample size by 64%, including more than 120,000 adults in 13 randomized trials worldwide. The findings demonstrated that those that took daily omega-3 fish oil supplements, compared to placebo, lowered their risk for most cardiovascular disease outcomes, including an 8% reduced risk for heart attack and coronary heart disease death. According to the researchers the risk reduction could translate to hundreds of thousands of CVD heart attacks and deaths averted world wide each year.

Evidence::Yang Hu. Frank B. Hu, et al. Marine Omega‐3 Supplementation and Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants. Journal of the American Heart Association. 2019;8:e013543. Mortazavi A, Nematipoor E, et al. The Effect of Omega-3 Fatty Acids on Serum Apelin Levels in Cardiovascular Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. Rep Biochem Mol Biol. 2018 Oct;7(1):59-66.

Why your clinic needs this platform

 

Over 90,000 documented drug-nutrient interactions, including:

  • 30,000+ drug–nutrient depletions (e.g., statins depleting CoQ10, PPIs reducing magnesium or B12)
     
  • 20,000+ absorption and bioavailability conflicts (e.g., calcium impairing iron or levothyroxine absorption)
     
  • 10,000+ metabolic pathway competition or inhibition cases (e.g., CYP450 interactions with grapefruit, folate, etc.)
     
  • 30,000+ clinically observed adverse or synergistic effects based on real-world pharmacovigilance and peer-reviewed data.
     

These interactions are cataloged across databases like:

  • Micromedex
     
  • Natural Medicines Database
     
  • FDA, NIH, and EMA pharmacogenomic repositories
     
  • PubMed-indexed peer-reviewed research
     
  • Clinical Pharmacology, Lexicomp, and DrugBank
     

⚠️ Bottom Line:
Most clinicians only know a fraction of these. Without AI or dedicated software, it's nearly impossible to catch them all in real time—making automation and cross-referencing essential for precision care and risk mitigation.


Top 50 High Risk Contra-indications

 

Critical Depletions (Can Lead to Deficiency or Dysfunction):

  1. Statins (e.g., Atorvastatin, Simvastatin) → ↓ CoQ10, Vitamin D
     
  2. Metformin → ↓ Vitamin B12, Folate
     
  3. Proton Pump Inhibitors (e.g., Omeprazole) → ↓ Magnesium, Calcium, B12, Iron
     
  4. Oral Contraceptives → ↓ B6, B2, B12, Folate, Vitamin C, Zinc, Magnesium
     
  5. Loop Diuretics (e.g., Furosemide) → ↓ Potassium, Magnesium, Calcium, Thiamine
     
  6. Thiazide Diuretics → ↓ Magnesium, Potassium, Zinc
     
  7. ACE Inhibitors → ↓ Zinc, ↑ Potassium
     
  8. Anticonvulsants (e.g., Phenytoin, Carbamazepine) → ↓ Vitamin D, Calcium, Folate, Biotin
     
  9. Corticosteroids (e.g., Prednisone) → ↓ Calcium, Potassium, Vitamin D
     
  10. Beta Blockers (e.g., Metoprolol) → ↓ CoQ10, Melatonin
     

Genetically Impacted Interactions (Methylation, Detox, Hormones):

  1. Methotrexate → ↓ Folate (esp. risky with MTHFR variants)
     
  2. SSRIs (e.g., Fluoxetine) → ↑ B6 depletion, interfere with melatonin production
     
  3. Valproic Acid → ↓ Carnitine
     
  4. Rifampin → ↓ Vitamin D, B6, Folate
     
  5. Levodopa/Carbidopa → ↓ B6
     
  6. Isoniazid → ↓ B6
     
  7. NSAIDs (e.g., Ibuprofen) → ↓ Iron absorption, gut barrier disruption
     
  8. Sulfonamides → ↓ Folate
     
  9. Cholestyramine → ↓ Fat-soluble vitamins (A, D, E, K)
     
  10. Phenobarbital → ↓ Vitamin D, K, Folate
     

Absorption Blockers / Bioavailability Conflicts:

  1. Calcium → ↓ Iron, Zinc, Magnesium absorption (dose-dependent)
     
  2. Iron supplements → ↓ Zinc, Magnesium, Calcium (competes at absorption sites)
     
  3. High-dose Zinc → ↓ Copper
     
  4. Magnesium (non-chelated) → ↓ Iron, Calcium when taken simultaneously
     
  5. Tetracycline antibiotics → ↓ Calcium, Magnesium, Iron (forms insoluble complexes)
     
  6. Levothyroxine + Iron/Calcium → ↓ Absorption of thyroid hormone
     
  7. Cholestyramine → ↓ CoQ10, Beta-carotene, Vitamin A
     
  8. Alcohol → ↓ B1 (thiamine), Magnesium, Zinc, Folate
     

Drug-Nutrient-Gene Triads (High Risk with Genetic Polymorphisms):

  1. Fluorouracil + DPYD variant → Lethal toxicity (no B6 metabolism)
     
  2. Nitrous oxide + MTRR/MTR/MTHFR variants → Functional B12 depletion
     
  3. Phenytoin + MTHFR C677T → ↑ Homocysteine
     
  4. Valproate + MTHFR/MTRR → ↑ Neural tube defect risk (folate depletion)
     
  5. SSRIs + COMT Val/Met → Altered dopamine/epinephrine metabolism
     
  6. Warfarin + Vitamin K → Narrow therapeutic window, requires monitoring
     
  7. Theophylline + CYP1A2 polymorphism → Toxicity or underdosing risk
     

Synergistic or Competitive Interactions:

  1. High-dose Vitamin E + Anticoagulants → ↑ Bleeding risk
     
  2. Fish Oil (EPA/DHA) + Antiplatelets → ↑ Bleeding time
     
  3. St. John’s Wort + SSRIs → Serotonin syndrome
     
  4. Green Tea Extract + Nadolol → ↓ Drug efficacy
     
  5. Grapefruit + CYP3A4 drugs → ↑ Drug levels (e.g., statins, calcium blockers)
     
  6. Caffeine + CYP1A2 inhibitors (e.g., fluvoxamine) → Caffeine toxicity
     
  7. Alcohol + Acetaminophen → Hepatotoxicity (especially with low glutathione)
     

Metabolic Load & Nutrient Demand Increasers:

  1. Smoking → ↓ Vitamin C, B6, Folate
     
  2. Chronic Stress → ↑ Magnesium, B5, B6, Vitamin C depletion
     
  3. Excess Exercise → ↑ Magnesium, Zinc, Iron, B-vitamins loss
     
  4. High sugar intake → ↓ Chromium, B-vitamins
     
  5. PPIs + Calcium Carbonate → ↓ Calcium absorption (requires acid)
     
  6. H2 Blockers (e.g., Ranitidine) → ↓ B12 and Iron over time
     
  7. Chronic antibiotics → ↓ B-vitamins and K2 via gut flora depletion
     
  8. Metronidazole → ↓ Vitamin B1, B9, and gut barrier stability

potential negative outcomes

 

Mitochondrial Dysfunction & Fatigue

Depletions: CoQ10, B-vitamins, Carnitine, Magnesium
Likely Outcomes:

  • Chronic fatigue
     
  • Muscle weakness
     
  • Statin-induced myopathy
     
  • Neuropathy
     
  • Poor exercise recovery
     

Cognitive Decline & Mood Instability

Depletions: B12, Folate, B6, Zinc, COMT/MTHFR-SNP + drug effects
Likely Outcomes:

  • Brain fog, memory issues
     
  • Depression, anxiety, irritability
     
  • Impaired methylation → ↑ homocysteine → neurovascular damage
     
  • Poor serotonin, dopamine clearance (SSRIs + COMT/MTHFR)
     

Cardiovascular Disease Risk

Drivers: ↑ Homocysteine (MTHFR/MTR/MTRR + drug impact), ↓ CoQ10, ↓ Magnesium, ↓ Vitamin D
Likely Outcomes:

  • Endothelial dysfunction
     
  • Hypertension
     
  • Arrhythmia
     
  • Arterial plaque development
     
  • Thrombosis or stroke risk
     

Poor Detoxification & Hormonal Imbalance

Depletions: SAMe, Glutathione, B6, B12, Folate, Magnesium, COMT overload
Likely Outcomes:

  • Estrogen dominance, PMS, fibroids
     
  • Estrogen-sensitive cancers (with impaired COMT)
     
  • Liver congestion, chemical sensitivity
     
  • Poor phase I/II detox efficiency (CYP450 burden)
     

Digestive & Nutrient Absorption Disorders

Drug effects: PPIs, H2 blockers, Antibiotics, Alcohol, Metformin
Likely Outcomes:

  • Bloating, GERD rebound
     
  • SIBO or gut dysbiosis
     
  • Iron, B12, magnesium, calcium deficiencies
     
  • Gut barrier breakdown → systemic inflammation
     

Musculoskeletal & Bone Health Decline

Depletions: Vitamin D, Calcium, Magnesium, Vitamin K2, Thiamine
Likely Outcomes:

  • Osteopenia, osteoporosis
     
  • Fracture risk
     
  • Muscle cramps, spasms
     
  • Postural instability in older adults
     

Drug Toxicity or Ineffectiveness

Due to: CYP inhibition (grapefruit, caffeine, St. John’s Wort), absorption interference (calcium, iron, fiber), or enzyme polymorphisms (CYP1A2, DPYD, COMT)
Likely Outcomes:

  • Overdosing (e.g., theophylline, warfarin, SSRIs)
     
  • Underdosing and therapy failure (e.g., levothyroxine, antihypertensives)
     
  • ADRs and ER visits
     
  • Treatment resistance misdiagnosis
     

Epigenetic & Methylation Damage

Due to: MTHFR, MTRR, MTR SNPs + folate/B12/B6 depletion
Likely Outcomes:

  • ↑ Homocysteine → DNA damage, vascular inflammation
     
  • Poor cellular repair
     
  • Fertility issues
     
  • Accelerated aging and chronic disease onset
     

⚠️ 9. Immune Dysregulation

Depletions: Zinc, Vitamin D, Vitamin A, B6
Likely Outcomes:

  • Increased infection risk
     
  • Poor vaccine response
     
  • Autoimmune flare-ups
     
  • Chronic inflammation and poor healing
     

🧪 10. Clinical Misdiagnosis & Polypharmacy Spiral

Due to: Symptom masking or worsening from unrecognized drug-nutrient interactions
Likely Outcomes:

  • Treating nutrient depletion symptoms with more drugs
     
  • Mislabeling side effects as new diagnoses
     
  • Escalating care costs and medication load
     
  • Reduced quality of life and therapeutic trust
     

Summary:

Unchecked drug–nutrient interactions lead to chronic fatigue, cognitive dysfunction, cardiovascular disease, hormone imbalances, weakened immunity, and toxic overload.
When combined with genetic vulnerabilities, these effects multiply—silently sabotaging outcomes unless proactively addressed.
 


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